So you have tried everything out there possible from the over the counter things you get at the pharmacy to the natural remedies like toothpaste and you just still have a terrible acne problem…you may want to check out proactiv solution. My sister swears by this stuff and she has really nice skin…she says it is because she uses this treatment all the time. She has been using it for 6 years now and she has never complained once or had any problems with it. Everyone’s skin is different though so you really have to try different things to see what works best for you and remember you have to give a product 3 months to see if it make a difference in your skin.